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      Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37.

      Journal of Bacteriology
      Antimicrobial Cationic Peptides, pharmacology, Bacterial Proteins, genetics, metabolism, Cathelicidins, Gene Expression Regulation, Bacterial, Humans, Intracellular Signaling Peptides and Proteins, Iron, Repressor Proteins, Streptococcal Infections, microbiology, Streptococcus pyogenes, drug effects, growth & development, Transcription, Genetic

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          Abstract

          We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.

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