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      Studies on the Hemodynamic Changes Induced by Electrical Stimulation of the Vagosympathetic Trunks in the Dog

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          Abstract

          The effects of electrostimulation of the cephalic endings of the vagosympathetic trunks on the systemic and perfusion pressure of the hind limb of the dog depend upon frequency, intensity and duration of the stimulus. The electrostimulation performed with stimuli of high frequency, low intensity and moderately long duration (rectangular waves of 1.5 V, 0.7 msec, 100 Hz) consistently elicited systemic hypertension and vasoconstriction. This response was completely abolished by pretreatment with guanethidine or hexamethonium. On the other hand, electrostimulation with stimuli of low frequency, high intensity and long duration (5 V, 1 msec, 10 Hz) produced systemic hypotension and vasodilatation in the perfused hind limb. These effects were completely blocked by atropine or hexamethonium, while guanethidine was unable to induce any modification. These findings suggest that electrostimulation of vagosympathetic trunks can evoke different hemodynamic responses depending upon the characteristics of the stimulus. The occurrence of a vasodilatation specifically blocked by atropine demonstrates that a purely cholinergic mechanism underlies such a reflex response.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1975
          1975
          29 October 2008
          : 60
          : 2
          : 98-112
          Affiliations
          Istituto di Patologia Speciale Medica e Metodologia Clinica, II Facoltà di Medicina e Chirurgia, Università di Napoli, Naples
          Article
          169708 Cardiology 1975;60:98–112
          10.1159/000169708
          1182719
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 15
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