2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      European Respiratory Society International Congress, Madrid, 2019: nontuberculous mycobacterial pulmonary disease highlights

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Once overlooked, awareness of nontuberculous mycobacterial pulmonary disease (NTM-PD) is rapidly rising, in line with increasing prevalence worldwide. The European Respiratory Society (ERS) International Congress 2019, held in Madrid, Spain, provided a platform for invigorating discussions and exciting new research in the field. This article explores approaches being taken to combat NTM-PD with a focus not only on novel prevalence and risk factor data, but also on emerging antimicrobials and their routes of delivery, and other potential treatment options in early clinical development.

          Abstract

          Emerging research provides an insight into future treatment approaches for nontuberculous mycobacterial pulmonary disease (NTM-PD) – a serious, chronic, infectious disease that often presents in patients with underlying respiratory disease https://bit.ly/31spZpE

          Related collections

          Most cited references57

          • Record: found
          • Abstract: not found
          • Article: not found

          An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review.

            Population-based data have documented a worldwide increase in the prevalence of human nontuberculous mycobacterial (NTM) infections since 2000. Mycobacterium avium complex is predominant in North America and East Asia, whereas in regions within Europe, M kansasii, M xenopi, and M malmoense are more common. Host factors important to the current epidemiology of NTM pulmonary disease include thoracic skeletal abnormalities, rheumatoid arthritis, and use of immunomodulatory drugs. Clustering of disease within families suggests a heritable genetic predisposition to disease susceptibility. Warm, humid environments with high atmospheric vapor pressure contribute to population risk.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.

              Within the past 10 years, treatment and diagnostic guidelines for nontuberculous mycobacteria have been recommended by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA). Moreover, the Clinical and Laboratory Standards Institute (CLSI) has published and recently (in 2011) updated recommendations including suggested antimicrobial and susceptibility breakpoints. The CLSI has also recommended the broth microdilution method as the gold standard for laboratories performing antimicrobial susceptibility testing of nontuberculous mycobacteria. This article reviews the laboratory, diagnostic, and treatment guidelines together with established and probable drug resistance mechanisms of the nontuberculous mycobacteria.
                Bookmark

                Author and article information

                Journal
                ERJ Open Res
                ERJ Open Res
                ERJOR
                erjor
                ERJ Open Research
                European Respiratory Society
                2312-0541
                October 2020
                19 October 2020
                : 6
                : 4
                : 00317-2020
                Affiliations
                [1 ]School of Medicine, University of Dundee, Dundee, UK
                [2 ]Chru Hôpitaux De Tours, Hôpital Bretonneau, Tours, France
                [3 ]ASST Great Metropolitan Hospital Niguarda, Milan, Italy
                [4 ]University Hospital Frankfurt, Frankfurt, Germany
                [5 ]Pneumologie, Centre Hospitalier Universitaire de la Réunion, Saint Pierre, Réunion
                [6 ]Liverpool Heart and Chest Hospital, Liverpool, UK
                Author notes
                James D. Chalmers, University of Dundee, Nethergate, Dundee, DD1 4HN, Scotland, UK. E-mail: j.chalmers@ 123456dundee.ac.uk
                Author information
                https://orcid.org/0000-0002-5193-7755
                Article
                00317-2020
                10.1183/23120541.00317-2020
                7569164
                33123559
                0818651f-159c-4887-9f82-d32c73879fe7
                Copyright ©ERS 2020

                This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

                History
                : 26 May 2020
                : 03 August 2020
                Funding
                Funded by: Insmed Incorporated
                Categories
                Congress Highlights
                4

                Comments

                Comment on this article