For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
19
views
140
references
 Top references
cited by
51
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      539
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Therapeutic Versatility of Resveratrol Derivatives

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Resveratrol, a natural phytoalexin, exhibits a remarkable range of biological activities, such as anticancer, cardioprotective, neuroprotective and antioxidant properties. However, the therapeutic application of resveratrol was encumbered for its low bioavailability. Therefore, many researchers focused on designing and synthesizing the derivatives of resveratrol to enhance the bioavailability and the pharmacological activity of resveratrol. During the past decades, a large number of natural and synthetic resveratrol derivatives were extensively studied, and the methoxylated, hydroxylated and halogenated derivatives of resveratrol received particular more attention for their beneficial bioactivity. So, in this review, we will summarize the chemical structure and the therapeutic versatility of resveratrol derivatives, and thus provide the related structure activity relationship reference for their practical applications.

          Related collections

          Most cited references140

          • Record: found
          • Abstract: found
          • Article: not found

          Bioavailability of resveratrol.

          Thomas Walle (2011)
          This paper reviews our current understanding of the absorption, bioavailability, and metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in humans is about 75% and is thought to occur mainly by transepithelial diffusion. Extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1%. Dose escalation and repeated dose administration of resveratrol does not appear to alter this significantly. Metabolic studies, both in plasma and in urine, have revealed major metabolites to be glucuronides and sulfates of resveratrol. However, reduced dihydroresveratrol conjugates, in addition to highly polar unknown products, may account for as much as 50% of an oral resveratrol dose. Although major sites of metabolism include the intestine and liver (as expected), colonic bacterial metabolism may be more important than previously thought. Deconjugation enzymes such as β-glucuronidase and sulfatase, as well as specific tissue accumulation of resveratrol, may enhance resveratrol efficacy at target sites. Resveratrol analogs, such as methylated derivatives with improved bioavailability, may be important in future research. © 2011 New York Academy of Sciences.
          Article 0 comments Cited 277 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Plant foods and herbal sources of resveratrol.

            Jennifer N Burns, Takao Yokota, Hiroshi Ashihara … (2002)
            Stilbenes, in particular trans-resveratrol and its glucoside, are widely reported to be beneficial to health, having been shown to possess antioxidative, anticarcinogenic, and antitumor properties. Major dietary sources include grapes, wine, peanuts, and soy; however, they can also be introduced into the diet through Itadori tea, which has long been used in Japan and China as a traditional herbal remedy for heart disease and strokes. Analysis of grapes, peanuts, and Itadori tea shows that they contain mainly trans-resveratrol glucoside. In contrast, red wines are primarily a source of the aglycones cis- and trans-resveratrol. While peanuts and grapes contain low levels of the stilbenes, Itadori tea and red wine both supply relatively high concentrations of resveratrol. For people who do not consume alcohol, Itadori tea may be a suitable substitute for red wine. However, further study on the potential biological effects of other endogenous compounds in Itadori tea is required and there is also a need for more information on the absorption and in vivo biomedical actions of free and conjugated resveratrol.
            Article 0 comments Cited 272 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The molecular targets of resveratrol.

              Sameer Kulkarni, Carles Cantó (2015)
              Resveratrol has emerged in recent years as a compound conferring strong protection against metabolic, cardiovascular and other age-related complications, including neurodegeneration and cancer. This has generated the notion that resveratrol treatment acts as a calorie-restriction mimetic, based on the many overlapping health benefits observed upon both interventions in diverse organisms, including yeast, worms, flies and rodents. Though studied for over a decade, the molecular mechanisms governing the therapeutic properties of resveratrol still remain elusive. Elucidating how resveratrol exerts its effects would provide not only new insights in its fundamental biological actions but also new avenues for the design and development of more potent drugs to efficiently manage metabolic disorders. In this review we will cover the most recent advances in the field, with special focus on the metabolic actions of resveratrol and the potential role of SIRT1 and AMPK. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
              Article 0 comments Cited 168 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Nutrients
                Journal ID (iso-abbrev): Nutrients
                Journal ID (publisher-id): nutrients
                Title: Nutrients
                Publisher: MDPI
                ISSN (Electronic): 2072-6643
                Publication date (Electronic): 29 October 2017
                Publication date Collection: November 2017
                Volume: 9
                Issue: 11
                Electronic Location Identifier: 1188
                Affiliations
                [1 ]College of Pharmacy, Dalian Medical University, Dalian 116044, China; imwaqasnawaz@ 123456yahoo.com (W.N.); dengsa31@ 123456163.com (S.D.); xiaodong.ma@ 123456139.com (X.M.); maxc1978@ 123456163.com (X.M.)
                [2 ]Academy of Integrative Medicine, Dalian Medical University, Dalian 116044, China; zzq0060@ 123456hotmail.com
                [3 ]The Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China
                Author notes
                [* ]Correspondence: li_chuangang@ 123456sina.com (C.L.); xiaohong_shu@ 123456dmu.edu.cn (X.S.); Tel.: +86-411-8611-0419 (C.L. & X.S.)
                Author information
                https://orcid.org/0000-0003-0299-1963
                Article
                Publisher ID: nutrients-09-01188
                DOI: 10.3390/nu9111188
                PMC ID: 5707660
                PubMed ID: 29109374
                SO-VID: 081a01a9-66e1-4852-9f24-858d8625ea4a
                Copyright © © 2017 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 15 August 2017
                Date accepted : 25 October 2017
                Categories
                Subject: Review

                ScienceOpen disciplines: Nutrition & Dietetics
                Keywords: resveratrol,resveratrol derivatives,pharmacological activity,structure-activity relationship
                Data availability:
                ScienceOpen disciplines: Nutrition & Dietetics
                Keywords: resveratrol, resveratrol derivatives, pharmacological activity, structure-activity relationship

                Comments

                Comment on this article

                scite_

                Similar content539

                See all similar

                Cited by50

                See all cited by

                Most referenced authors1,225

                See all reference authors