For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
6
views
17
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      577
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Sonographic Identification of Klippel-Trenaunay-Weber Syndrome

      case-report

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Klippel-Trenaunay-Weber syndrome is a rare cutaneous vascular disorder characterized by the presence of multiple hemangiomata, arteriovenous fistulas, and limb hypertrophy. We report the prenatal sonographic findings in a case of Klippel-Trenaunay-Weber (KTW) syndrome including fetal limb hypertrophy and large subcutaneous cystic lesions. Prenatal diagnosis is possible by ultrasound examination and recognition important for prevention of complications and future management.

          Related collections

          Most cited references17

          • Record: found
          • Abstract: found
          • Article: not found

          Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

          C. Raman Suri, P Maisonpierre, Benjamin Aldrich … (1997)
          Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2 receptor tyrosine kinase. Like vascular endothelial growth factor, Ang1 is essential for normal vascular development in the mouse. An Ang1 relative, termed angiopoietin-2 (Ang2), was identified by homology screening and shown to be a naturally occurring antagonist for Ang1 and Tie2. Transgenic overexpression of Ang2 disrupts blood vessel formation in the mouse embryo. In adult mice and humans, Ang2 is expressed only at sites of vascular remodeling. Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
          Article 0 comments Cited 340 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Klippel-Trenaunay syndrome: current management.

            P Gloviczki, Max D. Driscoll (2006)
            Klippel-Trenaunay syndrome (KTS) is a rare, sporadic, complex malformation characterized by the clinical triad of (1) capillary malformations (port wine stain); (2) soft tissue and bone hypertrophy or, occasionally, hypotrophy of usually one lower limb; and (3) atypical, mostly lateral varicosity. KTS is a mixed vascular malformation, with predominant capillary, venous and lymphatic components, without significant arteriovenous shunting. Management is largely conservative and the extent of diagnostic evaluation is determined by the planned treatment. Compression is the hallmark of conservative management; laser can be used to treat port wine stains. Imaging before vascular interventions must confirm venous anatomy and deep venous drainage. Techniques for ablation of superficial veins and malformations are individualized and may include sclerotherapy with alcohol or foam, endovenous thermal ablation or, as used most frequently in our practice, surgical stripping and phlebectomy. Intraoperative use of tourniquet will decrease bleeding, selective use of an inferior vena cava filter will prevent pulmonary embolism. A multidisciplinary approach to management of KTS is warranted.
            Article 0 comments Cited 20 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Klippel-Trenaunay syndrome: clinical features, complications and management in children.

              L Spitz, Leslie M. Samuel (1995)
              Clinical features and management of 47 children with Klippel-Trenaunay syndrome treated since 1970 were reviewed. Haemangiomas and soft tissue and/or skeletal hypertrophy were present in all 47 patients; venous varicosities developed in 37 (79 per cent). There was no clinical evidence of macrofistulous arteriovenous communications in any patient. Thromboembolic episodes occurred in five children (11 per cent) and 25 (53 per cent) experienced thrombophlebitis. The Kasabach-Merritt syndrome was observed in 21 (45 per cent) and six (13 per cent) presented with high-output cardiac failure. Other manifestations included haematuria in five (11 per cent), rectal or colonic haemorrhage in six (13 per cent), and vaginal, vulval or penile bleeding in six (13 per cent) children with visceral and pelvic haemangiomas. In 26 patients (55 per cent) symptomatic treatment only was required. Surgery was undertaken in selected cases for complications of the haemangioma, for cosmetic reasons and for chronic venous insufficiency. Only one of four children who underwent resection of varicose veins improved. There was no death, but significant morbidity was associated with the treatment of Kasabach-Merritt syndrome and high-output cardiac failure.
              Article 0 comments Cited 20 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Case Rep Obstet Gynecol
                Journal ID (iso-abbrev): Case Rep Obstet Gynecol
                Journal ID (publisher-id): CRIM.OBGYN
                Title: Case Reports in Obstetrics and Gynecology
                Publisher: Hindawi Publishing Corporation
                ISSN (Print): 2090-6684
                ISSN (Electronic): 2090-6692
                Publication date (Print): 2013
                Publication date (Electronic): 3 December 2013
                Volume: 2013
                Electronic Location Identifier: 595476
                Affiliations
                1Department of Obstetrics and Gynecology, Kocaeli University School of Medicine, Kocaeli 41000, Turkey
                2Department of Obstetrics and Gynecology, Maternal-Fetal Unit, Kocaeli University School of Medicine, Kocaeli 41000, Turkey
                Author notes
                *Sule Yildirim Kopuk: suleyildirim@ 123456msn.com

                Academic Editors: A. Awonuga, A. Semczuk, and E. Shalev

                Author information
                http://orcid.org/0000-0002-5020-8323
                Article
                DOI: 10.1155/2013/595476
                PMC ID: 3866887
                PubMed ID: 24368952
                SO-VID: 081e8757-3c63-46eb-b16e-25282f262928
                Copyright © Copyright © 2013 Yigit Cakiroglu et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 28 September 2013
                Date accepted : 6 November 2013
                Categories
                Subject: Case Report

                ScienceOpen disciplines: Obstetrics & Gynecology
                Data availability:
                ScienceOpen disciplines: Obstetrics & Gynecology

                Comments

                Comment on this article