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      Altering the genome by homologous recombination.

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      Science (New York, N.Y.)
      American Association for the Advancement of Science (AAAS)

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          Abstract

          Homologous recombination between DNA sequences residing in the chromosome and newly introduced, cloned DNA sequences (gene targeting) allows the transfer of any modification of the cloned gene into the genome of a living cell. This article discusses the current status of gene targeting with particular emphasis on germ line modification of the mouse genome, and describes the different methods so far employed to identify those rare embryonic stem cells in which the desired targeting event has occurred.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Jun 16 1989
          : 244
          : 4910
          Affiliations
          [1 ] Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City 84112.
          Article
          10.1126/science.2660260
          2660260
          083be386-8b60-4e26-a778-e89bc554b96e
          History

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