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      Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing

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          Abstract

          Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive Fe 3O 4/CNT and the chemotherapy agent gentamicin (Gent). This system, Fe 3O 4/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from Fe 3O 4/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections.

          Abstract

          Deep tissue infections can be difficult to treat due to limited light penetration associated with phototherapies. Here, the authors report on a bacterial capture system for antibiotic delivery and microwave-assisted killing of MRSA in osteomyelitis and demonstrate application in vivo.

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          Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

          Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.
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            A Deep Learning Approach to Antibiotic Discovery

            Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed predictions on multiple chemical libraries and discovered a molecule from the Drug Repurposing Hub-halicin-that is structurally divergent from conventional antibiotics and displays bactericidal activity against a wide phylogenetic spectrum of pathogens including Mycobacterium tuberculosis and carbapenem-resistant Enterobacteriaceae. Halicin also effectively treated Clostridioides difficile and pan-resistant Acinetobacter baumannii infections in murine models. Additionally, from a discrete set of 23 empirically tested predictions from >107 million molecules curated from the ZINC15 database, our model identified eight antibacterial compounds that are structurally distant from known antibiotics. This work highlights the utility of deep learning approaches to expand our antibiotic arsenal through the discovery of structurally distinct antibacterial molecules.
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              Enhanced Microwave Absorption Performance from Magnetic Coupling of Magnetic Nanoparticles Suspended within Hierarchically Tubular Composite

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                Author and article information

                Contributors
                liuxiangmei1978@163.com
                shuilinwu@tju.edu.cn
                Journal
                Nat Commun
                Nat Commun
                Nature Communications
                Nature Publishing Group UK (London )
                2041-1723
                7 September 2020
                7 September 2020
                2020
                : 11
                : 4446
                Affiliations
                [1 ]GRID grid.33763.32, ISNI 0000 0004 1761 2484, School of Materials Science & Engineering, , The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, ; Tianjin, 300072 China
                [2 ]GRID grid.34418.3a, ISNI 0000 0001 0727 9022, Hubei Key Laboratory of Polymer Materials, , Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, ; Wuhan, 430062 China
                [3 ]GRID grid.43169.39, ISNI 0000 0001 0599 1243, State Key Laboratory for Mechanical Behavior of Materials, , School of Materials Science and Engineering, Xi’an Jiaotong University, ; Xi’an, 710049 Shanxi China
                [4 ]GRID grid.11135.37, ISNI 0000 0001 2256 9319, College of Engineering, State Key Laboratory for Turbulence and Complex System, Department of Materials Science and Engineering, , Peking University, ; Beijing, 100871 China
                [5 ]GRID grid.194645.b, ISNI 0000000121742757, Department of Orthopaedics & Traumatology, , Li Ka Shing Faculty of Medicine, The University of Hong Kong, ; Pokfulam, Hong Kong, 999077 China
                [6 ]GRID grid.265021.2, ISNI 0000 0000 9792 1228, Stomatological Hospital, , Tianjin Medical University, ; Tianjin, 300070 China
                Author information
                http://orcid.org/0000-0002-6469-2363
                http://orcid.org/0000-0002-7402-9979
                http://orcid.org/0000-0001-7765-4027
                http://orcid.org/0000-0002-1270-1870
                Article
                18268
                10.1038/s41467-020-18268-0
                7477539
                32895387
                0840554b-6a1f-4993-8515-9ec9bcecc88e
                © The Author(s) 2020

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 24 April 2020
                : 14 August 2020
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                © The Author(s) 2020

                Uncategorized
                bacterial infection,antimicrobial therapy,biomedical engineering,bioinspired materials

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