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      A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.

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          Abstract

          To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-beta and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).

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          Author and article information

          Journal
          Nat Genet
          Nature genetics
          Springer Science and Business Media LLC
          1546-1718
          1061-4036
          Nov 2007
          : 39
          : 11
          Affiliations
          [1 ] Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK.
          Article
          ng.2007.18
          10.1038/ng.2007.18
          17934461
          0859fcf6-82c1-4867-b9a9-e55e07991a30
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