Genetic Variants Associated With Phenytoin-Related Severe Cutaneous Adverse Reactions

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Abstract

The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basis of phenytoin-related severe cutaneous adverse reactions remains unknown.

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Author and article information

Journal

Title: JAMA

Abbreviated Title: JAMA

Publisher: American Medical Association (AMA)

ISSN (Print): 0098-7484

Publication date Created: August 06 2014

Publication date (Print): August 06 2014

Volume: 312

Issue: 5

Page: 525

Affiliations

[1 ]Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan2Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan3College of Medicine, Chang Gung University, Taoyuan, Taiwa

[2 ]Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan

[3 ]Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan

[4 ]Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan3College of Medicine, Chang Gung University, Taoyuan, Taiwan

[5 ]Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan3College of Medicine, Chang Gung University, Taoyuan, Taiwan

[6 ]College of Medicine, Chang Gung University, Taoyuan, Taiwan6Department of Dermatology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan

[7 ]Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan7Department of Dermatology, Taipei Medical University–Wan Fang Hospital, Taipei, Taiwan

[8 ]College of Medicine, Chang Gung University, Taoyuan, Taiwan8Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan

[9 ]College of Medicine, Chang Gung University, Taoyuan, Taiwan9Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou, Taiwan

[10 ]College of Medicine, Chang Gung University, Taoyuan, Taiwan10Department of Pharmacy, Chang Gung Memorial Hospital, Kaohsiung, Taiwan

[11 ]College of Medicine, Chang Gung University, Taoyuan, Taiwan11Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan

[12 ]Department of Dermatology, Hospital Sultanah Aminah Johor Bahru, Johor, Malaysia

[13 ]Department of Dermatology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan

[14 ]Department of Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan

[15 ]Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan

[16 ]Department of Pediatrics, China Medicine University, Taichung, Taiwan

[17 ]Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan

[18 ]Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan

[19 ]Department of Dermatology, Course of Integrated Medicine, Osaka University Graduate School of Medicine, Suita, Japan

[20 ]Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China

[21 ]College of Medicine, Chang Gung University, Taoyuan, Taiwan21Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou, Taiwan22Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan

[22 ]College of Medicine, Chang Gung University, Taoyuan, Taiwan23Department of Plastic Surgery and Burn Center, Chang Gung Memorial Hospital, Linkou, Taiwan

[23 ]Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan

[24 ]College of Medicine, Chang Gung University, Taoyuan, Taiwan25Biostatistical Center for Clinical Research, Chang Gung Memorial Hospital, Linkou, Taiwan

[25 ]Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan

Article

DOI: 10.1001/jama.2014.7859

PubMed ID: 25096692

SO-VID: 0866afcc-1af5-420d-a226-9a28d76f71f5

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