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      Myeloid-derived suppressor cells as regulators of the immune system.

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          Abstract

          Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1741
          1474-1733
          Mar 2009
          : 9
          : 3
          Affiliations
          [1 ] Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA. dmitry.gabrilovich@moffitt.org
          Article
          nri2506 NIHMS176549
          10.1038/nri2506
          2828349
          19197294
          086d9dba-4c99-48d7-98a0-b2604ab8f233
          History

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