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      Changes in the Concentrations of Dehydroepiandrosterone Sulfate and Estriol in Maternal Plasma during Pregnancy: A Longitudinal Study in Healthy Women throughout Gestation and at Term

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          Abstract

          In a longitudinal study, the changes in plasma concentrations of dehydroepiandrosterone sulfate (DHAS) and total estriol (E<sub>3</sub>) were followed in 10 normal pregnant women throughout gestation at 8-10, 14-17,21-24,28-32, and 38 weeks as well as at the time of admission to the delivery room. The mean plasma concentration of DHAS decreased from 325 ± 38.2 μg/dl in early gestation to minimum levels of 120 ± 15.9 μg/dl at week 38. At delivery there was a 2-fold increase in plasma DHAS (205.3 ± 17.7 μg/dl). The mean total E<sub>3 </sub>plasma concentration increased from 6.53 ± 2.5 ng/ml at week 8-10 to 198.6 ± 30.3 ng/ml prior to delivery. The decrease in the DHAS plasma levels is caused by the elevated metabolic clearance rate throughout pregnancy. The increasing E<sub>3</sub> plasma levels are caused by increasing steroid production by the fetoplacental unit and reflect fetal well-being. The peak levels of DHAS and E<sub>3 </sub>as well as of other steroids of adrenal or placental origin at admission to the delivery room reflect increased maternal and fetal stress with the onset of labor. These longitudinal reference data determined by modern radioimmunoassay methodology are helpful for the prenatal diagnosis of congenital disorders with insufficient or absent fetoplacental function, and in the control of suppression of the fetal pituitary-adrenal axis during dexamethasone treatment in pregnancies with a female fetus affected with congenital adrenal hyperplasia.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1994
          1994
          05 December 2008
          : 42
          : 6
          : 278-281
          Affiliations
          Divisions of Pediatric Endocrinology, Departments of Pediatrics, Universities of aKiel, bErlangen, Germany
          Article
          184209 Horm Res 1994;42:278–281
          10.1159/000184209
          7698724
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

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