Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Journal ID (pmc): plosgen
Title:
PLoS Genetics
Publisher:
Public Library of Science
(San Francisco, USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date Collection:
September
2014
Publication date
(Electronic):
4
September
2014
Volume: 10
Issue: 9
Electronic Location Identifier: e1004606
Affiliations
[1
]John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida,
United States of America
[2
]Division of Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania,
United States of America
[3
]Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona,
United States of America
[4
]Department of Psychiatry & Behavioral Sciences, University of Miami, Miami, Florida,
United States of America
[5
]Department of Molecular Neuroscience, University College London, London, United Kingdom
[6
]New York Brain Bank, Columbia University, New York, New York, United States of America
[7
]Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida,
United States of America
[8
]Department of Neurological Sciences, Rush University, Chicago, Illinois, United States
of America
[9
]Department of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Harvard
Medical School, Boston, Massachusetts, United States of America
[10
]Group Health Research Institute, Seattle, Washington, United States of America
[11
]Department of Medicine, University of Washington, Seattle, Washington, United States
of America
[12
]Department of Human Genetics, University of Pittsburgh Graduate School of Public Health,
Pittsburgh, Pennsylvania, United States of America
[13
]Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh,
Pennsylvania, United States of America
[14
]Department of Neurology, University of Miami, Miami, Florida, United States of America
[15
]Department of Psychiatry, Vanderbilt University, Nashville, Tennessee, United States
of America
[16
]Department of Psychiatry, Mount Sinai Hospital, New York, New York, United States
of America
[17
]Department of Neurology, Oregon Health & Science University, Portland, Oregon, United
States of America
[18
]Biomedical Genetics, Boston University School of Public Health, Boston, Massachusetts,
United States of America
[19
]C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown,
Massachusetts, United States of America
[20
]Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis,
Indiana, United States of America
[21
]Department of Epidemiology and Biostatistics, Case Western Reserve University School
of Medicine, Cleveland, Ohio, United States of America
[22
]Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston,
Massachusetts, United States of America
[23
]Department of Epidemiology, National Alzheimer's Coordinating Center, University of
Washington, Seattle, Washington, United States of America
[24
]Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the
Aging Brain, Columbia University, New York, New York, United States of America
[25
]Department of Pathology (Neuropathology), Rush University Medical Center, Chicago,
Illinois, United States of America
[26
]Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia,
Pennsylvania, United States of America
[27
]Arizona Alzheimer's Consortium, Banner Alzheimer's Institute, Phoenix, Arizona, United
States of America
[28
]Department of Psychiatry, University of Arizona, Phoenix, Arizona, United States of
America
[29
]Department of Pathology, University of Washington, Seattle, Washington, United States
of America
Georgia Institute of Technology, United States of America
Author notes
The authors have declared that no competing interests exist.
Conceived and designed the experiments: GWB DWD MPF BG JAS EMR GDS TJM. Analyzed the
data: GWB GDS KH ACN ERM MH JJC LD JRG HG JDB LAF JLH MAPV. Contributed reagents/materials/analysis
tools: DWD MPF BG JAS EMR TJM AJM JH JPV SGY DAB PLDJ EBL PKC MIK JKK DCM PK BTH WAK
RPM JQT. Wrote the paper: GWB GDS TJM. Critically reviewed manuscript: KH ACN ERM
MH JJC LD JRG HG JDB LAF JH JLH MAPV DWD MPF BG JAS EMR AJM JPV SGY DAB PLDJ EBL PKC
MIK JKK DCM PK BTH WAK RPM JQT.
¶ Membership of the Alzheimer’s Disease Genetics Consortium (ADGC) is provided in
Text S1.
Article
Publisher ID:
PGENETICS-D-14-00298
DOI: 10.1371/journal.pgen.1004606
PMC ID: 4154667
PubMed ID: 25188341
SO-VID: 0895397a-ed0f-469e-9c4b-f7b0edea6aed
Copyright statement:
Copyright @
2014
License:
This is an open-access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
The National Institutes of Health, National Institute on Aging (NIH-NIA) supported
this work through the following grants: ADGC, U01 AG032984, RC2 AG036528; NACC, U01
AG016976; NCRAD, U24 AG021886; NIA LOAD, U24 AG026395, U24 AG026390; Banner Sun Health
Research Institute P30 AG019610; Boston University, P30 AG013846, U01 AG10483, R01
CA129769, R01 MH080295, R01 AG017173, R01 AG025259, R01AG33193; Columbia University,
P50 AG008702, R37 AG015473; Duke University, P30 AG028377, AG05128; Emory University,
AG025688; Group Health Research Institute, UO1 AG06781, UO1 HG004610; Indiana University,
P30 AG10133; Johns Hopkins University, P50 AG005146, R01 AG020688; Massachusetts General
Hospital, P50 AG005134; Mayo Clinic, P50 AG016574; Mount Sinai School of Medicine,
P50 AG005138, P01 AG002219; New York University, P30 AG08051, MO1RR00096, UL1 RR029893,
5R01AG012101, 5R01AG022374, 5R01AG013616, 1RC2AG036502, 1R01AG035137; Northwestern
University, P30 AG013854; Oregon Health & Science University, P30 AG008017, R01 AG026916;
Rush University, P30 AG010161, R01 AG019085, R01 AG15819, R01 AG17917, R01 AG30146;
TGen, R01 NS059873; University of Alabama at Birmingham, P50 AG016582, UL1RR02777;
University of Arizona, R01 AG031581; University of California, Davis, P30 AG010129;
University of California, Irvine, P50 AG016573, P50, P50 AG016575, P50 AG016576, P50
AG016577; University of California, Los Angeles, P50 AG016570; University of California,
San Diego, P50 AG005131; University of California, San Francisco, P50 AG023501, P01
AG019724; University of Kentucky, P30 AG028383, AG05144; University of Michigan, P50
AG008671; University of Pennsylvania, P30 AG010124; University of Pittsburgh, P50
AG005133, AG030653; University of Southern California, P50 AG005142; University of
Texas Southwestern, P30 AG012300; University of Miami, R01 AG027944, AG010491, AG027944,
AG021547, AG019757; University of Washington, P50 AG005136; Vanderbilt University,
R01 AG019085; and Washington University, P50 AG005681, P01 AG03991. The Kathleen Price
Bryan Brain Bank at Duke University Medical Center is funded by NINDS grant # NS39764,
NIMH MH60451 and by Glaxo Smith Kline. Genotyping of the TGEN2 cohort was supported
by Kronos Science. The TGen series was also funded by NIA grant AG041232, the Banner
Alzheimer's Foundation, The Johnnie B. Byrd Sr. Alzheimer's Institute, the Medical
Research Council, and the state of Arizona and also includes samples from the following
sites: Newcastle Brain Tissue Resource (funding via the Medical Research Council,
local NHS trusts and Newcastle University), MRC London Brain Bank for Neurodegenerative
Diseases (funding via the Medical Research Council), South West Dementia Brain Bank
(funding via numerous sources including the Higher Education Funding Council for England
(HEFCE), Alzheimer's Research Trust (ART), BRACE as well as North Bristol NHS Trust
Research and Innovation Department and DeNDRoN), The Netherlands Brain Bank (funding
via numerous sources including Stichting MS Research, Brain Net Europe, Hersenstichting
Nederland Breinbrekend Werk, International Parkinson Fonds, Internationale Stiching
Alzheimer Onderzoek), Institut de Neuropatologia, Servei Anatomia Patologica, Universitat
de Barcelona. ADNI Funding for ADNI is through the Northern California Institute for
Research and Education by grants from Abbott, AstraZeneca AB, Bayer Schering Pharma
AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech,
GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson and Johnson, Eli Lilly and Co.,
Medpace, Inc., Merck and Co., Inc., Novartis AG, Pfizer Inc, F. Hoffman-La Roche,
Schering-Plough, Synarc, Inc., Alzheimer's Association, Alzheimer's Drug Discovery
Foundation, the Dana Foundation, and by the National Institute of Biomedical Imaging
and Bioengineering and NIA grants U01 AG024904, RC2 AG036535, K01 AG030514. Support
was also from the Alzheimer's Association (LAF, IIRG-08-89720; MAP-V, IIRG-05-14147)
and the US Department of Veterans Affairs Administration, Office of Research and Development,
Biomedical Laboratory Research Program. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript.