Bahare Salehi1, Pia Lopez Jornet2, Eduardo Pons-Fuster López3, Daniela Calina4, Mehdi Sharifi-Rad5,*, Karina Ramírez-Alarcón6, Katherine Forman6, Marcos Fernández7, Miquel Martorell6,*, William N. Setzer8, Natália Martins9,10,*, Célia F. Rodrigues11, Javad Sharifi-Rad12,*
17 March 2019
Oral mucosal lesions have many etiologies, including viral or bacterial infections, local trauma or irritation, systemic disorders, and even excessive alcohol and tobacco consumption. Folk knowledge on medicinal plants and phytochemicals in the treatment of oral mucosal lesions has gained special attention among the scientific community. Thus, this review aims to provide a brief overview on the traditional knowledge of plants in the treatment of oral mucosal lesions. This review was carried out consulting reports between 2008 and 2018 of PubMed (Medline), Web of Science, Embase, Scopus, Cochrane Database, Science Direct, and Google Scholar. The chosen keywords were plant, phytochemical, oral mucosa, leukoplakia, oral lichen planus and oral health. A special emphasis was given to certain plants (e.g., chamomile, Aloe vera, green tea, and coffea) and plant-derived bioactives (e.g., curcumin, lycopene) with anti-oral mucosal lesion activity. Finally, preclinical (in vitro and in vivo) and clinical studies examining both the safety and efficacy of medicinal plants and their derived phytochemicals were also carefully addressed.
|Keywords:||phytochemicals, aloe vera, matricaria chamomilla, lycopene, curcumin, plant extracts, medicinal plants, oral mucosal lesions|