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      A pair of cyclopeptide epimers from the seeds of Celosia argentea

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          Abstract

          Two cyclopeptides, celogentin L ( 1) and its epimer lyciumin A ( 2) were firstly isolated from Celosia argentea L.. The planar structures of the two compounds were fully determined by spectroscopic data, including 1D-, 2D-NMR, and HR-ESI/MS. The absolute configurations of amino acid components were assigned via chiral-phase HPLC analyses after acid hydrolysis. Furthermore, the configuration of C-N linkage at the glycine Cα was elucidated by extensive analyses of 2D-NMR and comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Cytotoxicity of the two compounds against human alveolar epithelial A549, hepatocellular carcinoma HepG2, and cervical cancer Hela cell lines was assayed. Although both of them were inactive in these cells, the present findings add new facets for the chemistry of Celosia argentea.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 January 2018
          : 16
          : 1
          : 63-69
          Affiliations
          1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
          2Anhui Medical College, Hefei 230601, China
          3School of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
          Author notes
          *Corresponding authors: JIANG Yan, E-mails: jiangyancpu@ 123456126.com ; LI Hui-Jun, cpuli@ 123456163.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30030-X
          10.1016/S1875-5364(18)30030-X
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81322051
          Award ID: 31400300
          Funded by: Natural Science Foundation of Jiangsu Province
          Award ID: BK20151442
          This work was financially supported by the National Natural Science Foundation of China (Nos. 81322051 and 31400300), the Natural Science Foundation of Jiangsu Province (No. BK20151442), and the Project Funded by the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.

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