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Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia
C. Ertmer ,
A. Morelli ,
S. Rehberg ,
M. Lange ,
C. Hucklenbruch ,
H. Van Aken ,
M. Booke ,
M. Westphal
December 2007
December 2007
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Abstract
Hypodynamic septic shock is associated with a poor prognosis. The present randomized-controlled
laboratory experiment was designed to test the hypothesis that the vasodilatory peptide
hormone adrenomedullin (ADM) is a useful agent to prevent and reverse the development
of hypodynamic circulation in ovine endotoxaemia.