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      Stimulation of Prolactin Release by Angiotensin II in Superfused Rat Anterior Pituitary Cell Aggregates

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          Abstract

          Superfusion of rat anterior pituitary cell aggregates with 10-min pulses of 0.1–10 nM angiotensin II (AII) resulted in a prompt and concentration-dependent rise of PRLrelease. The effect could be blocked by saralasin, an AII receptor antagonist. The response to AII, but not that to TRH, was rapidly desensitized:a 10 nM AII pulse caused an 80% depression of the response to a subsequent 10 nM pulse given 50 min later. The data provide a possible functional significance for the renin-angiotensin system recently demonstrated in the anterior pituitary.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1983
          1983
          26 March 2008
          : 36
          : 6
          : 483-485
          Affiliations
          Laboratory of Cell Pharmacology, Department of Pharmacology, University of Leuven, School of Medicine, Campus Gasthuisberg, Leuven, Belgium
          Article
          123502 Neuroendocrinology 1983;36:483–485
          10.1159/000123502
          6410299
          © 1983 S. Karger AG, Basel

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          Page count
          Pages: 3
          Categories
          Rapid Communication

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