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      THE FINE STRUCTURE OF THE GALL BLADDER EPITHELIUM OF THE MOUSE

      research-article
      The Journal of Biophysical and Biochemical Cytology
      The Rockefeller University Press

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          Abstract

          Sections of mouse gall bladder epithelium fixed by perfusion with buffered osmium tetroxide have been studied in the electron microscope as an example of simple columnar epithelium. The free surface presents many microvilli, each presenting a dense tip, the capitulum, and displaying a radiating corona of delicate filaments, the antennulae microvillares. Very small pit-like depressions, representing caveolae intracellulares, are encountered along the cell membrane of the microvilli. The free cell surface between microvilli shows larger cave-like depressions, likewise representing caveolae intracellulares, containing a dense material. The lateral cell borders are extensively folded into pleats, which do not interdigitate extensively with corresponding folds of the adjacent cell membrane. The terminal bars are shown to consist of thickened densities of the cell membrane itself in the region of insertion of the lateral cell wall with the free cell surface. This thickening is associated with an accumulation of dense cytoplasmic material in the immediate vicinity. The terminal bar is thus largely a cytoplasmic and cell membrane structure, rather than being primarily intercellular in nature. The basal cell membrane is relatively straight except for a conical eminence near the center of the cell, projecting slightly into the underlying tunica propria. The basal cell membrane itself is overlain by a delicate limiting membrane, which does not follow the lateral contours of the cell. Unmyelinated intercellular nerve terminals with synaptic vesicles have been encountered between the lateral walls of epithelial cells. A division of the gall bladder epithelial cell into five zones according to Ferner has been found to be convenient for this study. The following cytoplasmic components have been noted, and their distribution and appearance described: dense absorption granules, mitochondria, Golgi or agranular membranes, endoplasmic reticulum or ergastoplasm, ring figures, and irregular dense bodies, perhaps lipoid in nature. The nucleus of these cells is also described.

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          Author and article information

          Journal
          J Biophys Biochem Cytol
          jcb
          The Journal of Biophysical and Biochemical Cytology
          The Rockefeller University Press
          0095-9901
          25 September 1955
          : 1
          : 5
          : 445-458
          Affiliations
          (From the Department of Anatomy, University of Washington, Seattle)
          Article
          10.1083/jcb.1.5.445
          2229656
          13263332
          08db2b03-5eb2-4440-a5da-ae334de19c30
          Copyright © Copyright, 1955, by The Rockefeller Institute for Medical Research
          History
          : 15 June 1955
          Categories
          Article

          Biochemistry
          Biochemistry

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