- Record: found
- Abstract: not found
- Article: not found
Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer
November 2009
November 2009
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Nanoscale drug delivery systems using liposomes and nanoparticles are emerging technologies
for the rational delivery of chemotherapeutic drugs in the treatment of cancer. Their
use offers improved pharmacokinetic properties, controlled and sustained release of
drugs and, more importantly, lower systemic toxicity. The commercial availability
of liposomal Doxil and albumin-nanoparticle-based Abraxane has focused attention on
this innovative and exciting field. Recent advances in liposome technology offer better
treatment of multidrug-resistant cancers and lower cardiotoxicity. Nanoparticles offer
increased precision in chemotherapeutic targeting of prostate cancer and new avenues
for the treatment of breast cancer. Here we review current knowledge on the two technologies
and their potential applications to cancer treatment.