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      Two new nimbolinin- and trichilin-class limonoids isolated from the fruits of Melia azedarach

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          Abstract

          Two new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, which belonged to nimbolinin- and trichilin-class, respectively. Compound 2 exhibited weak inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with IC50 being 37.41 µmol-L –1.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 March 2019
          : 17
          : 3
          : 227-230
          Affiliations
          1 Testing & Analysis Center, Nanjing Normal University, Nanjing 210023, China
          2 Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
          Author notes
          *Corresponding author: LI Yi, Tel/Fax: 86-25-83326900, E-mail: liyi16@163.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30025-1
          10.1016/S1875-5364(19)30025-1
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81573550
          This study was supported by the National Natural Science Foundation of China (No. 81573550) and the Outstanding Youth Fund of the Basic Research Program of Jiangsu Province (BK20160077).

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