2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Connexin 43 and Mitochondria in Cardiovascular Health and Disease.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Connexin 43 (Cx43) is the major connexin protein in ventricular cardiomyocytes. Six Cx43 proteins assemble into so-called hemichannels at the sarcolemma and opposing hemichannels form gap junctions, which allow the passage of small molecules and electrical current flow between adjacent cells. Apart from its localization at the plasma membrane, Cx43 is also present in cardiomyocyte mitochondria, where it is important for mitochondrial function in terms of oxygen consumption and potassium fluxes. The expression of gap junctional and mitochondrial Cx43 is altered under several pathophysiological conditions among them are hypertension, hypertrophy, hypercholesterolemia, ischemia/reperfusion injury, post-infarction remodeling, and heart failure. The present review will focus on the role of Cx43 in cardiovascular diseases and will highlight the importance of mitochondrial Cx43 in cardioprotection.

          Related collections

          Author and article information

          Journal
          Adv. Exp. Med. Biol.
          Advances in experimental medicine and biology
          Springer Nature America, Inc
          0065-2598
          0065-2598
          2017
          : 982
          Affiliations
          [1 ] Institute of Physiology, Justus-Liebig University, Giessen, Germany.
          [2 ] Institute of Physiology, Justus-Liebig University, Giessen, Germany. Rainer.Schulz@physiologie.med.uni-giessen.de.
          Article
          10.1007/978-3-319-55330-6_12
          28551790
          08e921e6-c472-4c83-9f84-d4983a619f93
          History

          Ischemia/Reperfusion,Connexin 43,Mitochondria,Phosphorylation,Cardioprotection

          Comments

          Comment on this article