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      Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?

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          Abstract

          Fecal microbiota transplantation (FMT) is gaining considerable traction as a therapeutic approach to influence the course of a plethora of chronic conditions, ranging from metabolic syndrome and malignancies to auto-immune and neurological diseases, and helped to establish the contribution of the gut microbiome to these conditions. Although FMT procedures have yielded important mechanistic insights, their use in clinical practice may be limited due to practical objections in the setting of metabolic diseases. While its applicability is established to treat recurrent Clostridiodes difficile, FMT is emerging in ulcerative colitis and various other diseases. A particularly new insight is that FMTs may not only alter insulin sensitivity but may also alter the course of type 1 diabetes by attenuating underlying auto-immunity. In this review, we will outline the major principles and pitfalls of FMT and where optimization of study design and the procedure itself will further advance the field of cardiometabolic medicine.

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          Author and article information

          Journal
          Cell Metab
          Cell metabolism
          Elsevier BV
          1932-7420
          1550-4131
          Jun 01 2021
          : 33
          : 6
          Affiliations
          [1 ] Amsterdam Diabetes Centrum, Internal and Vascular Medicine, Amsterdam UMC, location AMC, Amsterdam, the Netherlands.
          [2 ] Laboratory of Microbiology, Wageningen University, Wageningen, the Netherlands; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
          [3 ] Amsterdam Diabetes Centrum, Internal and Vascular Medicine, Amsterdam UMC, location AMC, Amsterdam, the Netherlands. Electronic address: m.nieuwdorp@amsterdamumc.nl.
          Article
          S1550-4131(21)00222-9
          10.1016/j.cmet.2021.05.005
          34077717
          0904b937-1126-4eb1-b05f-6628986d09cb
          History

          diabetes,fecal microbiota transplant,metabolites,microbiome,responders

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