The Hidden Power of Black Pepper: Exploring Piperine’s Role in Cancer

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Abstract

Cancer is a multifaceted disease that occurs when cells proliferate and migrate in an uncontrolled and unregulated manner. The development of cancer is the result of the interaction of a number of factors, including genetic mutations, environmental factors and lifestyle habits. There are many pharmacological and natural compounds that can be used to prevent and/or treat cancer. Piperine, a naturally occurring compound with multiple therapeutic properties, is the primary bioactive component of black pepper ( Piper nigrum L.), a member of the Piperaceae plant family. In recent years, it has attracted much interest as a potentially useful agent for the preventive and curative management of cancer. Results from studies of human cancer cell lines and advanced animal tumour models suggest that there are multiple pathways by which piperine may affect cancer development and metastasis. This review examines the molecular and cellular mechanisms through which piperine exerts its effects on cancer formation and progression, as well as its potential effects on various types of cancer.

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Author and article information

Contributors

Nevin Sanlier:

ORCID: http://orcid.org/0000-0001-5937-0485

nevintekgul@gmail.com

Journal

Journal ID (nlm-ta): Plant Foods Hum Nutr

Journal ID (iso-abbrev): Plant Foods Hum Nutr

Title: Plant Foods for Human Nutrition (Dordrecht, Netherlands)

Publisher: Springer US (New York )

ISSN (Print): 0921-9668

ISSN (Electronic): 1573-9104

Publication date (Electronic): 29 May 2025

Publication date PMC-release: 29 May 2025

Publication date (Print): 2025

Volume: 80

Issue: 3

Electronic Location Identifier: 129

Affiliations

Department of Nutrition and Dietetics, School of Health Sciences, Ankara Medipol University, ( https://ror.org/01c9cnw16) 06050 Altındag, Ankara, Turkey

Author information

Ezgi Nur Cinar http://orcid.org/0000-0001-9620-6748

Nevin Sanlier http://orcid.org/0000-0001-5937-0485

Article

Publisher ID: 1374

DOI: 10.1007/s11130-025-01374-z

PMC ID: 12122619

PubMed ID: 40439931

SO-VID: 0914d51b-466f-4873-b733-b18f362d8729

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date accepted : 18 May 2025

Funding

Funded by: Ankara Medipol University

Open Access :

Open access funding provided by the Scientific and Technological Research Council of Türkiye (TÜBİTAK).

Custom metadata

ScienceOpen disciplines: Nutrition & Dietetics

Keywords: anticancer,black pepper,natural therapeutic agents,piperine,piper nigrum l

Data availability:

ScienceOpen disciplines: Nutrition & Dietetics

Keywords: anticancer, black pepper, natural therapeutic agents, piperine, piper nigrum l

The Hidden Power of Black Pepper: Exploring Piperine’s Role in Cancer

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