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      XBB.1.16 Omicron subvariant rise to a variant of interest: Implications for global alertness and preparedness

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          Abstract

          The emergence of the XBB.1.16 Omicron subvariant of COVID-19 has been a cause for concern for the WHO and health authorities globally. This subvariant, which originated from a hybrid of two BA.2 progeny pedigree, has two amino acid mutations in its spike protein and shares a genetic makeup similar to the XBB.1.5 variant. The WHO initially labeled it as a variant under monitoring before elevating it to a variant of interest after it was found to have caused a surge of COVID-19 cases in India for seven months. The XBB.1.16 subvariant has a proliferative edge and can evade the immune system. It has been spreading rapidly on a global scale and has been linked with a higher effective reproductive number than other subvariants. As such, a concerted international effort to prevent and contain its transmission has been recommended. Health authorities must strengthen their health systems, surveillance, and data collection systems to enable them to detect, track, and respond to emerging and reemerging strains of the virus in a timely and effective manner. Research into the XBB.1.16 subvariant is crucial for alerting and preparing the global populace for a potential outbreak, developing treatment options, and potential vaccines. Implementing the One Health approach can promote greater collaboration between diverse disciplines and societal levels to build a more resilient and sustainable future for all.

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          The emergence of BtSY2 Covid-like virus: A call for global preparedness

          Scientists in China announced on 25th of November with great concern that there is a new Covid-like virus out of the five viruses of concern discovered among bats across Yunnan province. It was reported that this Covid-like virus BtSY2 has high potential of infecting humans as it comprises a receptor binding domain which is a vital part of the spike protein used to lay hold of human cells and subsequently utilize human ACE2 receptor for cell entry similar to the SARS-CoV-2. In a bid to address this global threat in affected countries , it is expedient for authorized health professionals, policy makers and the world to keep an eye on this Covid-like virus capable of spreading from bats to humans because most pandemic outbreaks in recent decades have arisen in such a manner. Strict actions should be implemented in impeding transmission to humans which is paramount to battling viral diseases as learnt from history that viral outbreaks are very impossible to eradicate after global outbreak. Health officials and the World Health Organization should invest urgently in more research to further study this new Covid-like virus with an approach to prepare for a possible viral outbreak, and develop treatment options and possible vaccines to outsmart the danger posed to human health.
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            Pandemic origins and a One Health approach to preparedness and prevention: solutions based on SARS-CoV-2 and other RNA viruses

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              Sustaining communicable disease elimination efforts in the Americas in the wake of COVID-19

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                Author and article information

                Journal
                J Taibah Univ Med Sci
                J Taibah Univ Med Sci
                Journal of Taibah University Medical Sciences
                Taibah University. Production and hosting by Elsevier Ltd.
                1658-3612
                23 May 2023
                23 May 2023
                Affiliations
                [a ]Department of Medical Laboratory Science, Neuropsychiatric Hospital, Aro, Abeokuta, Nigeria
                [b ]Department of Medical Laboratory Science, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria
                [c ]Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom
                [d ]Department of Pharmaceutics, ISF College of Pharmacy, Moga, India
                Author notes
                []Corresponding author: Department of Medical Laboratory Science, Neuropsychiatric Hospital, Aro, Abeokuta, Nigeria.
                Article
                S1658-3612(23)00080-X
                10.1016/j.jtumed.2023.05.013
                10203986
                37250814
                091540e2-31bc-4cc5-b9d1-9b6f99c727ae
                © 2023 Taibah University. Production and hosting by Elsevier Ltd.

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                : 2 May 2023
                : 13 May 2023
                Categories
                Letter to the Editor

                global alertness,global preparedness,omicron subvariant,outbreaks,xbb.1.16

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