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      A computer program for aligning a cDNA sequence with a genomic DNA sequence.

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      Journal: Genome research

      Keywords: Sequence Homology, Nucleic Acid, Software, DNA, genetics, Computational Biology, DNA, Complementary, Drosophila melanogaster, Expressed Sequence Tags, Genome, Humans, Mice, RNA, Messenger, Sequence Alignment, methods, Algorithms, Animals

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          Abstract

          We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

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          • Record: found
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          Basic Local Alignment Search Tool

           S Altschul (1990)
          Article 0 comments Cited 1444 times – based on 0 reviews     Review now
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            dbEST--database for "expressed sequence tags".

             M S Boguski,  A. J. Lowe,  C Tolstoshev (1993)
            Article 0 comments Cited 315 times – based on 0 reviews     Review now
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              EST_GENOME: a program to align spliced DNA sequences to unspliced genomic DNA.

               Kevin Mott (1997)
              Article 0 comments Cited 69 times – based on 0 reviews     Review now
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                Author and article information

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                PMC ID:: 310774
                PubMed ID:: 9750195

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                ScienceOpen disciplines: Chemistry

                Keywords: Sequence Homology, Nucleic Acid, Software, DNA, genetics, Computational Biology, DNA, Complementary, Drosophila melanogaster, Expressed Sequence Tags, Genome, Humans, Mice, RNA, Messenger, Sequence Alignment, methods, Algorithms, Animals

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