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      A computer program for aligning a cDNA sequence with a genomic DNA sequence.

      Genome research

      Sequence Homology, Nucleic Acid, Software, DNA, genetics, Computational Biology, DNA, Complementary, Drosophila melanogaster, Expressed Sequence Tags, Genome, Humans, Mice, RNA, Messenger, Sequence Alignment, methods, Algorithms, Animals

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          Abstract

          We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

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          Most cited references 22

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          Basic Local Alignment Search Tool

           S Altschul (1990)
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            dbEST--database for "expressed sequence tags".

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              EST_GENOME: a program to align spliced DNA sequences to unspliced genomic DNA.

               Kevin Mott (1997)
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                Author and article information

                Journal
                310774
                9750195

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