High body mass index and risk of exacerbations and pneumonias in individuals with chronic obstructive pulmonary disease: observational and genetic risk estimates from the Copenhagen General Population Study.

Abstract

In the clinic, the combination of obesity and chronic obstructive pulmonary disease (COPD) has been increasing. However, whether high body mass index (BMI) affects the risk of exacerbations and pneumonias in individuals with COPD is presently unknown. Genetics can be used to assess the causal role of high BMI in exacerbations and pneumonias in individuals with COPD. We tested the hypothesis that high BMI is associated with an increased risk of exacerbations and pneumonias in individuals with COPD, both observationally and genetically.

Journal

Journal ID (iso-abbrev): Int J Epidemiol

Title: International journal of epidemiology

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1464-3685

ISSN (Print): 0300-5771

Publication date (Electronic): Oct 2016

Volume: 45

Issue: 5

Affiliations

[1 ] Department of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

[2 ] Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark.

[3 ] Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

[4 ] Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

[5 ] Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

[6 ] Medical Unit, Respiratory Section, Hvidovre Hospital, Copenhagen University Hospital, Hvidovre, Denmark.

[7 ] Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark [e-mail].

Article

Publisher Item ID: dyw051

DOI: 10.1093/ije/dyw051

PubMed ID: 27118560