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      High body mass index and risk of exacerbations and pneumonias in individuals with chronic obstructive pulmonary disease: observational and genetic risk estimates from the Copenhagen General Population Study.

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          Abstract

          In the clinic, the combination of obesity and chronic obstructive pulmonary disease (COPD) has been increasing. However, whether high body mass index (BMI) affects the risk of exacerbations and pneumonias in individuals with COPD is presently unknown. Genetics can be used to assess the causal role of high BMI in exacerbations and pneumonias in individuals with COPD. We tested the hypothesis that high BMI is associated with an increased risk of exacerbations and pneumonias in individuals with COPD, both observationally and genetically.

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          Author and article information

          Journal
          Int J Epidemiol
          International journal of epidemiology
          Oxford University Press (OUP)
          1464-3685
          0300-5771
          Oct 2016
          : 45
          : 5
          Affiliations
          [1 ] Department of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
          [2 ] Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark.
          [3 ] Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
          [4 ] Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
          [5 ] Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
          [6 ] Medical Unit, Respiratory Section, Hvidovre Hospital, Copenhagen University Hospital, Hvidovre, Denmark.
          [7 ] Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark Boerge.Nordestgaard@regionh.dk.
          Article
          dyw051
          10.1093/ije/dyw051
          27118560

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