Distinct neural mechanisms underlie the success, precision, and vividness of episodic memory

Abstract

A network of brain regions have been linked with episodic memory retrieval, but limited progress has been made in identifying the contributions of distinct parts of the network. Here, we utilized continuous measures of retrieval to dissociate three components of episodic memory: retrieval success, precision, and vividness. In the fMRI scanner, participants encoded objects that varied continuously on three features: color, orientation, and location. Participants’ memory was tested by having them recreate the appearance of the object features using a continuous dial, and continuous vividness judgments were recorded. Retrieval success, precision, and vividness were dissociable both behaviorally and neurally: successful versus unsuccessful retrieval was associated with hippocampal activity, retrieval precision scaled with activity in the angular gyrus, and vividness judgments tracked activity in the precuneus. The ability to dissociate these components of episodic memory reveals the benefit afforded by measuring memory on a continuous scale, allowing functional parcellation of the retrieval network.

DOI: http://dx.doi.org/10.7554/eLife.18260.001

eLife digest

Remembering is something we do countless times each day. The detail and vividness with which we can remember is part of what makes memories so precious. Given the significance and complexity of memories, it is perhaps unsurprising that several parts of the brain are needed for us to experience them. Indeed, the brain regions involved in memory all work so closely together that it is a challenge to identify what role each region plays.

Richter, Cooper et al. aimed to design a memory task that could separate key characteristics of remembering, which would allow them to study links between each aspect and the different brain regions involved in memory. The resulting test involved showing people images of different objects whilst they were in an MRI medical imaging scanner. The people taking the test were asked to remember several objects that could vary in color, position and orientation. Participants were asked to rate how vividly they remembered the objects and then tried to precisely recreate their color, orientation and position.

The test allowed Richter, Cooper et al. to link specific parts of the brain to certain aspects of remembering. The hippocampus, an area known to be important in memory processing, indicated whether or not information had been remembered. More vivid memories were linked to greater activity in a region called the precuneus, which plays a role in imagination. Lastly, activity in a third region – the angular gyrus – indicated the precision of each memory.

Being able to study different aspects of memory using tests like this that collect detailed measurements could be important in identifying memory problems, for example, in people with brain diseases or head injuries, or after a stroke. Specifically, the methods developed by Richter, Cooper et al. could provide sensitive tools for detecting memory difficulties at an early stage. This may help more people to get treated sooner, potentially minimizing lasting complications.

DOI: http://dx.doi.org/10.7554/eLife.18260.002