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      [Role of apoptosis signal-regulating kinase 1 (ASK 1)-mediated signaling pathway during ischemic retinal injury].

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      Nippon Ganka Gakkai zasshi

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          Abstract

          Apoptosis signal-regulating kinase 1(ASK 1) is one of a growing number of mitogen-activated protein kinase (MAPK) kinase kinases identified in the c-Jun N-terminal kinase and p38 MAPK pathways. ASK 1 mediates diverse biological signals leading to cell death, differentiation, survival, and senescence, in response to cellular stress and the innate immune response. In the retina, ASK 1 is mainly expressed in retinal ganglion cells, and loss of ASK 1 leads to mild damage after ischemic injury. Consistently, ASK 1 deficient retinal ganglion cells were resistant to hydrogen peroxide. Our findings suggest that ASK 1 is involved in retinal cell death due to oxidative stress and may be a new therapeutic target for retinal degeneration.

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          Author and article information

          Journal
          Nippon Ganka Gakkai Zasshi
          Nippon Ganka Gakkai zasshi
          0029-0203
          0029-0203
          Nov 2008
          : 112
          : 11
          Affiliations
          [1 ] Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu-shi, Tokyo 183-8526, Japan. charada@tmin.ac.jp
          Article
          19069379
          093f8e01-02c2-437e-a424-5ccdeedb7fbb
          History

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