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      Transcriptional control of human p53-regulated genes.

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          Abstract

          The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          May 2008
          : 9
          : 5
          Affiliations
          [1 ] The Institute for Advanced Study, Princeton, New Jersey, USA. triley@ias.edu
          Article
          nrm2395
          10.1038/nrm2395
          18431400
          0961cec1-a781-4014-8184-01eedcc0ced9
          History

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