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      Mitochondria and apoptosis.

      Science (New York, N.Y.)
      American Association for the Advancement of Science (AAAS)

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          Abstract

          A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.

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          Journal
          9721092
          10.1126/science.281.5381.1309

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