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      Relationship of Antibody Localization to Lesions in Nephrotoxic Serum Nephritis

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      Nephron

      S. Karger AG

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          Abstract

          Administration of a potent rabbit anti-rat kidney serum to intact as well as bilaterally-nephrectomized rats failed to produce ultrastructural alteration in lungs or adrenal cortices despite localization of the heterologous γ-globulin in these tissues. Quantitative measurements disclosed the 7S globulin fractions of NTS and NRS to be slightly greater in lungs of nephrectomized rats than intact members after their injection, although no apparent difference in such localization was evident by immunofluorescence. Complement was observed only in kidneys following injection of NTS. The results fail to substantiate the occurrence of extrarenal lesions in this system and to indicate that their absence is not necessarily dependent upon quantity of localized anti-basement membrane antibody. They also suggest the importance of fixed complement in this regard.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1971
          1971
          26 November 2008
          : 8
          : 6
          : 566-574
          Affiliations
          Departments of Pathology, Shadyside Hospital and University of Pittsburgh School of Medicine, Pittsburgh, Pa.
          Article
          179962 Nephron 1971;8:566–574
          10.1159/000179962
          4109407
          © 1971 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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