Relationship of Antibody Localization to Lesions in Nephrotoxic Serum Nephritis

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Abstract

Administration of a potent rabbit anti-rat kidney serum to intact as well as bilaterally-nephrectomized rats failed to produce ultrastructural alteration in lungs or adrenal cortices despite localization of the heterologous γ-globulin in these tissues. Quantitative measurements disclosed the 7S globulin fractions of NTS and NRS to be slightly greater in lungs of nephrectomized rats than intact members after their injection, although no apparent difference in such localization was evident by immunofluorescence. Complement was observed only in kidneys following injection of NTS. The results fail to substantiate the occurrence of extrarenal lesions in this system and to indicate that their absence is not necessarily dependent upon quantity of localized anti-basement membrane antibody. They also suggest the importance of fixed complement in this regard.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1971

Publication date (Print): 1971

Publication date (Electronic): 26 November 2008

Volume: 8

Issue: 6

Pages: 566-574

Affiliations

Departments of Pathology, Shadyside Hospital and University of Pittsburgh School of Medicine, Pittsburgh, Pa.

Article

Publisher ID: 179962 Other ID: Nephron 1971;8:566–574

DOI: 10.1159/000179962

PubMed ID: 4109407

SO-VID: 0978ffd6-3cd4-4a86-aab9-c7bb34042908

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Relationship of Antibody Localization to Lesions in Nephrotoxic Serum Nephritis

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Karger: Nephrology

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