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Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway.
N Ouchi
1 ,
S Kihara ,
Y Arita ,
Y Okamoto ,
K Maeda ,
H Kuriyama ,
K Hotta ,
M Nishida ,
M Takahashi ,
M Muraguchi ,
Y Ohmoto ,
T Nakamura ,
S Yamashita ,
T Funahashi ,
Y Matsuzawa
Sep 12 2000
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Abstract
Among the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated that adiponectin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules and that plasma adiponectin level was reduced in patients with coronary artery disease (CIRCULATION: 1999;100:2473-2476). However, the intracellular signal by which adiponectin suppressed adhesion molecule expression was not elucidated. The present study investigated the mechanism of modulation for endothelial function by adiponectin.