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      Role of iron supplementation in promoting maternal and fetal outcome

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          Abstract

          Background

          The data comparing daily versus intermittent iron supplementation during pregnancy remain controversial. This study was undertaken to compare the efficacy of daily versus two different intermittent iron supplementation regimes on hematologic markers and birth outcomes in nonanemic pregnant women.

          Methods

          Two hundred and ten women with singleton pregnancies, no known disease, and hemoglobin levels >11.0 g/dL were randomly assigned to one of three groups, ie, Group A consuming two iron supplementation tablets once weekly (100 mg iron per week, n = 70), Group B consuming one tablet twice weekly (100 mg iron per week, n = 70) and Group C, consuming one tablet daily (50 mg iron per day, n = 70). No additional micronutrients were supplied. Hemoglobin and serum ferritin levels were measured at 20, 28, and 38 weeks. Pregnancy and birth outcomes (pregnancy termination, method of delivery, birth weight, stillbirth) were analyzed.

          Results

          In total, 201 women completed the protocol. There was a significant difference in mean hemoglobin and ferritin levels in Group B at 38 weeks ( P = 0.018 and P = 0.035, respectively) but this difference was not clinically significant (hemoglobin >12 g/dL, ferritin >19 μg/L). There was a significant increase in ferritin in Group C ( P = 0.03) at 28 weeks. No significant difference was observed with respect to pregnancy or birth outcome across the groups. All regimens prevented the occurrence of hemoglobin <10.5 g/dL, but weekly supplementation was associated with development of a hemoglobin level <11.0 g/dL (risk ratio 0.044).

          Conclusion

          Twice-weekly supplementation is as effective as daily supplementation, and may represent an acceptable compromise in iron supplementation regimens for nonanemic pregnant women.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2011
          2011
          31 October 2011
          : 7
          : 421-428
          Affiliations
          [1 ]Department of Community Medicine, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran
          [2 ]Medical Demonstration Facility, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran
          [3 ]Institute of Cell and Molecular Science, London, United Kingdom
          [4 ]Student Research Committee, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran
          [5 ]Department of Obstetrics and Gynecology, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran
          [6 ]Department of Mycology and Parasitology, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran
          Author notes
          Correspondence: Mohammad Ghasemi-rad, Student Research Committee, Urmia University of Medical Sciences, Djahad St, PO Box 1138, Urmia, Islamic Republic of Iran, Tel +98 91 4343 5284, Fax +98 44 12353 3561, Email medman11@ 123456gmail.com
          tcrm-7-421
          10.2147/TCRM.S16892
          3233526
          22162919
          © 2011 Yekta et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Original Research

          Medicine

          pregnancy, iron supplementation, outcome, anemia

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