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      The involvement of pineal gland and melatonin in immunity and aging I. Thymus-mediated, immunoreconstituting and antiviral activity of thyrotropin-releasing hormone

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      Journal of Neuroimmunology

      Elsevier BV

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          Abstract

          Circadian, continued treatment with melatonin during the dark cycle produces changes in the blood level of thyroid hormones in aging mice. Thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH) antagonize the involution of the thymus produced by prednisolone. This effect of TRH does not seem thyroid dependent. TRH restores antibody production in non-responder athymic nude mice but does not exert this effect in neonatally thymectomized mice. Moreover, this activity does not correlate with thyroxine levels. TRH exerts a powerful protective effect in mice challenged with encephalomyocarditis (EMC) virus. Presumably pineal melatonin exerts its varied regulatory functions via hypothalamic TRH.

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          Author and article information

          Journal
          Journal of Neuroimmunology
          Journal of Neuroimmunology
          Elsevier BV
          01655728
          May 1990
          May 1990
          : 27
          : 2-3
          : 99-109
          Article
          10.1016/0165-5728(90)90059-V
          2159021
          © 1990

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