Oestrone Sulphatase Activity of the Rat Uterus in Different Hormonal States

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Abstract

Oestrone sulphatase activity was determined in the 12,500 g supernatant of rat uterus homogenates. The conditions used were 0.5 mM oestrone sulphate and 30 min incubation at pH 8.0 and 37 °C. The enzyme activity in uteri from normal animals was found to be 5.1 ± 0.7 nmol (mg protein)<sup>-1</sup>h-<sup>1</sup>. In ovariectomized and hypophysectomized animals the values were significantly higher, whereas subcutaneous administration of 17 β-oestradiol to such rats resulted in significantly decreased oestrone sulphatase activities. Progesterone increased the enzyme activity of intact rats. It is concluded that the uterine tissue of rats contains oestrone sulphatase which may be of biological importance and which is inhibited by oestrogen.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1980

Publication date (Print): 1980

Publication date (Electronic): 25 November 2008

Volume: 13

Issue: 3

Pages: 180-185

Affiliations

Hormone Laboratory, University of Bergen School of Medicine, Haukeland Sykehus, Bergen, Norway

Article

Publisher ID: 179285 Other ID: Horm Res 1980;13:180–185

DOI: 10.1159/000179285

PubMed ID: 7203400

SO-VID: 09a31ad9-6d42-41c2-9c3b-fbcd3d8f65ed

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 22 October 1979

Date accepted : 11 August 1980

Page count

Pages: 6

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