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      Patients with Primary Sjögren's Syndrome Have Alterations in Absolute Quantities of Specific Peripheral Leucocyte Populations

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          Prediction of Sjögren's Syndrome Years Before Diagnosis and Identification of Patients With Early Onset and Severe Disease Course by Autoantibody Profiling.

          Autoantibodies are highly characteristic of primary Sjögren's syndrome (SS) and represent important tools for studying its pathogenesis. Nonetheless, thus far, no systematic investigations have assessed the presence of autoantibodies before diagnosis. This study was undertaken to analyze how early and in what order autoantibodies appear, how predictive they are of primary SS, and whether they identify disease subsets.
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            Autoantibodies present before symptom onset in primary Sjögren syndrome.

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              Is Open Access

              Role of neutrophils in systemic autoimmune diseases

              Neutrophils have emerged as important regulators of innate and adaptive immune responses. Recent evidence indicates that neutrophils display marked abnormalities in phenotype and function in various systemic autoimmune diseases, and may play a central role in initiation and perpetuation of aberrant immune responses and organ damage in these conditions. This review discusses the putative roles that neutrophils and aberrant neutrophil cell death play in the pathogenesis of various systemic autoimmune diseases, including systemic lupus erythematosus, small vessel vasculitis and rheumatoid arthritis.
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                Author and article information

                Journal
                Scandinavian Journal of Immunology
                Scand J Immunol
                Wiley-Blackwell
                03009475
                December 2017
                December 26 2017
                : 86
                : 6
                : 491-502
                Article
                10.1111/sji.12622
                29072325
                09c1eb30-f150-435d-9671-5529052acbc2
                © 2017

                http://doi.wiley.com/10.1002/tdm_license_1.1

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