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      Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade.

      Cell

      Animals, Anti-Mullerian Hormone, Base Sequence, Binding Sites, Cell Nucleus, metabolism, DNA, genetics, DNA-Binding Proteins, Female, Fushi Tarazu Transcription Factors, Gene Expression Regulation, Glycoproteins, Growth Inhibitors, Homeodomain Proteins, Humans, Male, Mice, Molecular Sequence Data, Mullerian Ducts, embryology, Promoter Regions, Genetic, Rats, Rats, Sprague-Dawley, Receptors, Cytoplasmic and Nuclear, Sertoli Cells, Sex Characteristics, Sex Differentiation, physiology, Steroidogenic Factor 1, Testicular Hormones, Testis, Transcription Factors, Transcriptional Activation

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          Abstract

          Normal male sex differentiation requires that Sertoli cells in the embryonic testes produce müllerian inhibiting substance (MIS), a TGF beta-like hormone that causes müllerian duct regression. In primary Sertoli cells, the orphan nuclear receptor, steroidogenic factor 1 (SF-1), regulates the MIS gene by binding to a conserved upstream regulatory element. In heterologous (HeLa) cells, MIS gene activation by SF-1 requires removal of the SF-1 ligand-binding domain, implicating a Sertoli cell-specific ligand or cofactor. Finally, the sexually dimorphic expression of SF-1 during development coincides with MIS expression and müllerian duct regression. We propose that SF-1 regulates MIS in vivo and participates directly in the process of mammalian sex determination.

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          8205615

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