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      Tratamiento de la hiperpotasemia severa en pediatría, a propósito de un caso Translated title: Treatment of severe hyperkalemia in pediatrics, a case report

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Resumen A propósito un caso de hiperpotasemia severa en un paciente con insuficiencia renal crónica ingresado en nuestra unidad de cuidados intensivos pediátricos, en el presente artículo, revisamos las causas y el tratamiento de la hiperpotasemia severa en pacientes pediátricos en el medio hospitalario.

          Translated abstract

          Abstract Severe hyperkalemia is an electrolyte alteration that may result in life-threatening consequences. In this case report, we review the causes and treatment of severe hyperkalemia in paediatric patients and describe the case of a patient with end-stage renal disease, suffering from this electrolyte alteration after major surgery.

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          Effects of pH on potassium: new explanations for old observations.

          Peter S Aronson, Gerhard Giebisch (2011)
          Maintenance of extracellular K(+) concentration within a narrow range is vital for numerous cell functions, particularly electrical excitability of heart and muscle. Potassium homeostasis during intermittent ingestion of K(+) involves rapid redistribution of K(+) into the intracellular space to minimize increases in extracellular K(+) concentration, and ultimate elimination of the K(+) load by renal excretion. Recent years have seen great progress in identifying the transporters and channels involved in renal and extrarenal K(+) homeostasis. Here we apply these advances in molecular physiology to understand how acid-base disturbances affect serum potassium.
          Article 0 comments Cited 69 times – based on 0 reviews     Review now
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            Electrocardiographic manifestations: electrolyte abnormalities.

            George M Shumaik, Deborah B Diercks, Mark Harrigan … (2004)
            Because myocyte depolarization and repolarization depend on intra- and extracellular shifts in ion gradients, abnormal serum electrolyte levels can have profound effects on cardiac conduction and the electrocardiogram (EKG). Changes in extracellular potassium, calcium, and magnesium levels can change myocyte membrane potential gradients and alter the cardiac action potential. These changes can result in incidental findings on the 12-lead EKG or precipitate potentially life-threatening dysrhythmias. We will review the major electrocardiographic findings associated with abnormalities of the major cationic contributors to cardiac conduction-potassium, calcium and magnesium.
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              Emergency management of severe hyperkalemia: Guideline for best practice and opportunities for the future.

              Patrick Rossignol, Matthieu Legrand, Mikhail Kosiborod … (2016)
              Hyperkalemia is a common electrolyte disorder, especially in chronic kidney disease, diabetes mellitus, or heart failure. Hyperkalemia can lead to potentially fatal cardiac dysrhythmias, and it is associated with increased mortality. Determining whether emergency therapy is warranted is largely based on subjective clinical judgment. The Investigator Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT) aimed to evaluate the current knowledge pertaining to the emergency treatment of hyperkalemia. The INI-CRCT developed a treatment algorithm reflecting expert opinion of best practices in the context of current evidence, identified gaps in knowledge, and set priorities for future research. We searched PubMed (to August 4, 2015) for consensus guidelines, reviews, randomized clinical trials, and observational studies, limited to English language but not by publication date. Treatment approaches are based on small studies, anecdotal experience, and traditional practice patterns. The safety and real-world effectiveness of standard therapies remain unproven. Prospective research is needed and should include studies to better characterize the population, define the serum potassium thresholds where life-threatening arrhythmias are imminent, assess the potassium and electrocardiogram response to standard interventions. Randomized, controlled trials are needed to test the safety and efficacy of new potassium binders for the emergency treatment of severe hyperkalemia in hemodynamically stable patients. Existing emergency treatments for severe hyperkalemia are not supported by a compelling body of evidence, and they are used inconsistently across institutions, with potentially significant associated side effects. Further research is needed to fill knowledge gaps, and definitive clinical trials are needed to better define optimal management strategies, and ultimately to improve outcomes in these patients.
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                Author and article information

                Journal
                Journal ID (publisher-id): ofil
                Title: Revista de la OFIL
                Abbreviated Title: Rev. OFIL·ILAPHAR
                Publisher: Organización de Farmacéuticos Ibero-Latinoamericanos (Madrid, Madrid, Spain )
                ISSN (Print): 1131-9429
                ISSN (Electronic): 1699-714X
                Publication date (Print and electronic): June 2022
                Volume: 32
                Issue: 2
                Pages: 209-210
                Affiliations
                [1] Sevilla orgnameHospital Universitario Virgen del Rocío orgdiv1Servicio de Farmacia España hector.rodriguez.sspa@ 123456juntadeandalucia.es
                Article
                Publisher ID: S1699-714X2022000200016 Publisher ID: S1699-714X(22)03200200016
                DOI: 10.4321/s1699-714x2022000200016
                SO-VID: 09cbd22a-eb13-4e5a-a502-b47018e01043
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                Date accepted : 18 January 2021
                Date received : 17 December 2020
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 8, Pages: 2
                Product

                SciELO Spain

                Categories
                Subject: Casos Clínicos

                Keywords: Alteraciones electrolíticas,cuidados intensivos pediátricos,pediatría,hiperpotasemia,paediatric intensive care,paediatrics,hyperkalemia,Electrolitic imbalance
                Data availability:
                Keywords: Alteraciones electrolíticas, cuidados intensivos pediátricos, pediatría, hiperpotasemia, paediatric intensive care, paediatrics, hyperkalemia, Electrolitic imbalance

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