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      [Progress on anti-tumor molecular mechanisms of dihydroartemisinin].

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          Abstract

          Artemisinin is an anti-malarial drug with poor water solubility and oral absorption; so a variety of derivatives based on the parent nucleus have been developed. Compared with artemisinin, dihydroartemisinin (DHA) has a stronger anti-malaria activity, and has the advantages of high metabolic rate and better water solubility. Recent studies have discovered that DHA has a good inhibitory effect on tumor cells, which is closely related to the peroxide bridge in its molecular structure. Since tumor cells need more Fe3+ than normal cells, there are a large number of transferrin receptors on the tumor cell membrane. DHA can break the peroxide bridge in the presence of Fe2+, and the free radicals generated can play its lethal effect on tumor cells. In addition, DHA can promote endocytosis of transferrin receptor, and thus prevent cancer cells from taking Fe3+ from microenvironment. This article reviews the anti-tumor molecular mechanism of DHA, including accelerating oxidative damage, inducing apoptosis, inhibiting the growth, proliferation and invasion of tumor cells, reversing tumor multidrug resistance.

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          Author and article information

          Journal
          Zhejiang Da Xue Xue Bao Yi Xue Ban
          Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
          1008-9292
          1008-9292
          May 25 2016
          : 45
          : 5
          Affiliations
          [1 ] College of Life Science, Northeast Forest University, Harbin 150040, China.
          [2 ] College of Life Science, Northeast Forest University, Harbin 150040, China. xyli821187@163.com.
          Article
          28087910
          09d0b341-f596-466b-9dff-cf1197f5f8d6
          History

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