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      Aptamers as targeted therapeutics: current potential and challenges

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      Nature Reviews Drug Discovery
      Springer Nature

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          Abstract

          Nucleic acid aptamers offer several advantages over traditional antibodies, but their clinical translation has been delayed by several factors, including insufficient potency, lack of safety data and high production costs. Here, Zhou and Rossi provide an overview of aptamer generation, focusing on recent technological advances and clinical development, as well as challenges and lessons learned.

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          Author and article information

          Journal
          Nature Reviews Drug Discovery
          Nat Rev Drug Discov
          Springer Nature
          1474-1776
          1474-1784
          November 3 2016
          November 3 2016
          :
          :
          Article
          10.1038/nrd.2016.199
          5700751
          27807347
          09e69fe8-31e3-4971-9599-5939f0137cac
          © 2016
          History

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