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Scaffolds and Cell-Based Tissue Engineering for Blood Vessel Therapy.

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      Abstract

      The increasing morbidity of cardiovascular diseases in modern society has made it crucial to develop a small-caliber blood vessel. In the absence of appropriate autologous vascular grafts, an alternative prosthesis must be constructed for cardiovascular disease patients. The aim of this article is to describe the advances in making cell-seeded cardiovascular prostheses. It also discusses the combinations of types of scaffolds and cells, especially autologous stem cells, which are suitable for application in tissue-engineered vessels with the favorable properties of mechanical strength, antithrombogenicity, biocompliance, anti-inflammation, fatigue resistance and long-term durability. This article highlights the advancements in cellular tissue-engineered vessels in recent years.

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      Author and article information

      Journal
      Cells Tissues Organs (Print)
      Cells, tissues, organs
      S. Karger AG
      1422-6421
      1422-6405
      2016
      : 202
      : 5-6
      27548610
      000448169
      10.1159/000448169

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