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      Incidence and Risk Factors for Nontuberculous Mycobacterial Infection after Allogeneic Hematopoietic Cell Transplantation.

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          Abstract

          Allogenic hematopoietic stem cell transplant (HCT) recipients are at risk of many infections. Nontuberculous mycobacteria (NTM) are increasingly recognized as clinically significant pathogens in this population. We investigated the incidence and risk factors for NTM infection after allogeneic HCT. This retrospective cohort study included all patients with allogeneic HCT at our institution during 2001 to 2013. Patients who developed significant NTM infection (NTM disease) were identified. Multivariable modeling was used to identify risk factors for NTM disease, and a risk score model was constructed to identify high-risk patients. Of 1097 allogeneic HCT patients, 45 (4.1%) had NTM isolated and 30 (2.7%) had NTM disease (28 [93.3%] exclusively pulmonary, 2 [6.7%] pulmonary plus another site). Incidence of NTM infection by competing risk analysis was 2.8% at 5 years (95% CI, 1.9% to 4.0%). The median time to diagnosis was 343 days (range, 19 to 1967). In Fine-Gray proportional hazards modeling, only global severity of chronic graft-versus-host disease (cGVHD) (HR, 1.99; 95% CI, 1.12 to 3.53; P = .019,) and cytomegalovirus (CMV) viremia (HR, 5.77; 95% CI, 1.71 to 19.45; P = .004) were significantly associated with NTM disease. Using these variables a risk score was calculated: 1 point for CMV viremia or moderate cGVHD and 2 points for severe cGVHD. The score divided patients into low risk (0 to 1 points, n = 820 [77.3%], 3-year NTM risk 1.2%), intermediate risk (2 points, n = 161 [15.4%], 3-year NTM risk 7.1%), and high risk (3 points, n = 56 [5.4%], 3-year NTM risk 14.3%). NTM disease after allogeneic HCT is common. Severe cGVHD and CMV viremia are associated with increased risk, permitting risk stratification.

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          Author and article information

          Journal
          Biol. Blood Marrow Transplant.
          Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
          Elsevier BV
          1523-6536
          1083-8791
          February 2018
          : 24
          : 2
          Affiliations
          [1 ] Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
          [2 ] Allogeneic Blood and Marrow Transplant Program, Department of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
          [3 ] Department of Medicine, Division of Respirology, University Health Network and University of Toronto, Toronto, Ontario, Canada. Electronic address: ted.marras@uhn.ca.
          Article
          S1083-8791(17)30748-6
          10.1016/j.bbmt.2017.09.015
          28986190
          09f9f5cf-a181-41f2-bc7d-98f917ebb54f
          History

          Nontuberculous mycobacteria,Mycobacterium infections,Hematopoietic stem cell transplantation,Allogeneic hematopoietic stem cell transplantation,Nontuberculous

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