SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.

Abstract

Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous antioxidant defenses maintaining the steady-state levels of O2·(-); no wonder, thus, that their mimics are remarkably efficacious in essentially any animal model of oxidative stress injuries thus far explored.