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      In vitro evolution and analysis of HIV-1 LTR-specific recombinases

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      Methods
      Elsevier BV

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          Abstract

          Current antiretroviral therapies would greatly benefit from the concurrent removal of integrated HIV-1 proviral DNA from the patient's cells. In this review, we describe an experimental strategy that allowed the engineering and functional analysis of a HIV-1 LTR-specific recombinase (Tre-recombinase). We furthermore provide protocols that are utilized for the investigation of Tre's antiretroviral activity in infected tissue cultures as well as in infected humanized Rag2(-/-)γc(-/-) mice. Copyright © 2010 Elsevier Inc. All rights reserved.

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          Author and article information

          Journal
          Methods
          Methods
          Elsevier BV
          10462023
          January 2011
          January 2011
          : 53
          : 1
          : 102-109
          Article
          10.1016/j.ymeth.2010.06.014
          20600935
          0a12ca4f-bcfb-4afe-8c98-da05d467387a
          © 2011

          https://www.elsevier.com/tdm/userlicense/1.0/

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