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      Obesity is not associated with contrast nephropathy

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          Abstract

          Background:

          Exposure to radiocontrast media may result in acute kidney injury (AKI) or traditionally defined contrast nephropathy (CN), both of which may lead to increased morbidity and mortality. The pathogenesis of both these variants of contrast-induced nephropathy (CIN) may involve inflammatory mediators that lead to renal impairment. A link between obesity and inflammation has been clearly established, but whether obesity is independently associated with CIN is unknown.

          Objective:

          To determine whether obesity, when stratified by body mass index (BMI), is a risk factor for CIN in a large and hemodynamically stable population of hospitalized United States veterans.

          Design:

          Retrospective chart review.

          Measurements:

          Presence or absence of AKI or CN after intravenous radiocontrast administration and comparison of patient characteristics between those with versus without AKI or CN.

          Results:

          The overall prevalence of AKI and CN was 16.1% and 12.6%, respectively. Patients with AKI or CN were comparable to those without radiocontrast injury, except that affected patients tended to be older and diabetic. When stratified by BMI, obesity was not found to be associated with the development of AKI or CN after exposure to radiocontrast.

          Conclusion:

          Obesity does not appear to be an independent risk factor for AKI or CN after exposure to radiocontrast.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2010
          2010
          25 May 2010
          : 6
          : 213-217
          Affiliations
          [1 ]Section of Nephrology, VA Loma Linda Healthcare System
          [2 ]Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA
          Author notes
          Correspondence: Navin Jaipaul, VA Loma Linda Healthcare System, 11201 Benton St (111N), Loma, Linda, CA 92357, USA, Tel +1 909 583 6090, Fax +1 909 777 3858, Email navin.jaipaul@ 123456va.gov
          Article
          tcrm-6-213
          2878954
          20526376
          © 2010 Jaipaul et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Original Research

          Medicine

          kidney injury, contrast nephropathy, obesity

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