We investigated whether a unique didactic focusing on delivering health care to patients with disabilities (PWDs) impacts medical students' knowledge of specific disabilities and related concerns, attitudes about barriers to this populations' health care, and behavior during typical primary care visits with PWDs. A 90-minute session for students during their third-year family medicine clerkship addressed clinical considerations for patients with mobility and cognitive impairments. Questionnaires were administered to students at the beginning and completion of the clerkship. Analyses of 71 matched questionnaires reveal that knowledge and attitudes were positively impacted.