For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
28
views
41
references
 Top references
cited by
26
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      215
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Antifungal Activity of Denture Soft Lining Material Modified by Silver Nanoparticles—A Pilot Study

      research-article

      Read this article at

      ScienceOpenPublisherPMC
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Soft liner materials in oral cavity environments are easily colonized both by fungi and dental plaque. These factors are the cause of mucosal infections. The microorganism that most frequently colonizes soft liner materials is Candida albicans. Colonization occurs on the surface of materials and within materials. A solution to this problem might involve modification of soft liner materials with silver nanoparticles (AgNPs). In this article, we present results showing the antifungal efficacy of silicone soft lining materials modified with AgNPs. The modification process was conducted by dissolving both material components (base and catalyst) in a colloidal solution of AgNPs and evaporating the solvent. Composites with various AgNP concentrations (10, 20, 40, 80, 120 and 200 ppm) were examined. The in vitro antifungal efficacy (AFE) of composite samples was 16.3% to 52.5%.

          Related collections

          Most cited references41

          • Record: found
          • Abstract: found
          • Article: not found

          Nanosilver: a nanoproduct in medical application.

          X Chen, H J Schluesener (2008)
          Nanotechnology is a most promising field for generating new applications in medicine. However, only few nanoproducts are currently in use for medical purposes. A most prominent nanoproduct is nanosilver. Nanosilver particles are generally smaller than 100nm and contain 20-15,000 silver atoms. At nanoscale, silver exhibits remarkably unusual physical, chemical and biological properties. Due to its strong antibacterial activity, nanosilver coatings are used on various textiles but as well as coatings on certain implants. Further, nanosilver is used for treatment of wounds and burns or as a contraceptive and marketed as a water disinfectant and room spray. Thus, use of nanosilver is becoming more and more widespread in medicine and related applications and due to increasing exposure toxicological and environmental issues need to be raised. In sharp contrast to the attention paid to new applications of nanosilver, few studies provide only scant insights into the interaction of nanosilver particle with the human body after entering via different portals. Biodistribution, organ accumulation, degradation, possible adverse effects and toxicity are only slowly recognized and this review is focusing on major questions associated with the increased medical use of nanosilver and related nanomaterials.
          Article 0 comments Cited 425 times – based on 0 reviews     Review now
            • Record: found
            • Abstract: found
            • Article: not found

            Nanosilver as a new generation of nanoproduct in biomedical applications.

            Karla Chaloupka, Yogeshkumar Malam, Alexander M Seifalian (2010)
            Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that NS has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings for wounds and burns. The key to its broad-acting and potent antibacterial activity is the multifaceted mechanism by which NS acts on microbes. This is utilized in antibacterial coatings on medical devices to reduce nosocomial infection rates. Many new synthesis methods have emerged and are being evaluated for NS production for medical applications. NS toxicity is also critically discussed to reflect on potential concerns before widespread application in the medical field. Copyright © 2010 Elsevier Ltd. All rights reserved.
            Article 0 comments Cited 356 times – based on 0 reviews     Review now
              • Record: found
              • Abstract: found
              • Article: not found

              Antifungal activity of silver nanoparticles against Candida spp.

              Ales Panacek, Milan Kolář, Renata Vecerova … (2009)
              The antifungal activity of the silver nanoparticles (NPs) prepared by the modified Tollens process was evaluated for pathogenic Candida spp. by means of the determination of the minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), and the time-dependency of yeasts growth inhibition. Simultaneously the cytotoxicity of the silver NPs to human fibroblasts was determined. The silver NPs exhibited inhibitory effect against the tested yeasts at the concentration as low as 0.21 mg/L of Ag. The inhibitory effect of silver NPs was enhanced through their stabilization and the lowest MIC equal to 0.05 mg/L was determined for silver NPs stabilized by sodium dodecyl sulfate against Candida albicans II. The obtained MICs of the silver NPs and especially of the stabilized silver NPs were comparable and in some cases even better than MICs of the conventional antifungal agents determined by E-test. The silver NPs effectively inhibited the growth of the tested yeasts at the concentrations below their cytotoxic limit against the tested human fibroblasts determined at a concentration equal to 30 mg/L of Ag. In contrast, ionic silver inhibited the growth of the tested yeasts at the concentrations comparable to the cytotoxic level (approx. 1mg/L) of ionic silver against the tested human fibroblasts.
              Article 0 comments Cited 217 times – based on 0 reviews     Review now
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: Molecular Diversity Preservation International (MDPI)
                ISSN (Electronic): 1422-0067
                Publication date Collection: 2011
                Publication date (Electronic): 22 July 2011
                Volume: 12
                Issue: 7
                Pages: 4735-4744
                Affiliations
                [1 ]Department of Materials Technology, Silesian University of Technology, ul. Krasińskiego 8, 40-019 Katowice, Poland; E-Mail: Jaroslaw.Zmudzki@ 123456polsl.pl
                [2 ]Chair and Department of Microbiology and Immunology in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland; E-Mails: amertas@ 123456sum.edu.pl (A.M.); teresa-nalewajek@ 123456wp.pl (T.N.); wkrol@ 123456sum.edu.pl (W.K.)
                [3 ]Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland; E-Mails: Izabela.Barszczewska-Rybarek@ 123456polsl.pl (I.B-R.); jan.lukaszczyk@ 123456polsl.pl (J.Ł.)
                Author notes
                [* ]Author to whom correspondence should be addressed; E-Mail: chladek@ 123456interia.pl ; Tel.: +48-603-498-128; Fax: +48-326-034-469.
                Article
                Publisher ID: ijms-12-04735
                DOI: 10.3390/ijms12074735
                PMC ID: 3155381
                PubMed ID: 21845108
                SO-VID: 0a3758f7-6111-4a58-9c33-d9593b50a3c2
                Copyright © © 2011 by the authors; licensee MDPI, Basel, Switzerland.
                License:

                This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                Date received : 23 June 2011
                Date revision received : 14 July 2011
                Date accepted : 18 July 2011
                Categories
                Subject: Article

                ScienceOpen disciplines: Molecular biology
                Keywords: soft liner,dental materials,antifungal,silver nanoparticles,candida albicans,nanotechnology in dentistry
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: soft liner, dental materials, antifungal, silver nanoparticles, candida albicans, nanotechnology in dentistry

                Comments

                Comment on this article

                Related Documents Log
                scite_

                Similar content215

                See all similar

                Cited by26

                See all cited by

                Most referenced authors245

                See all reference authors