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      The effect of parathyroid hormone and teriparatide on fracture healing.

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          Abstract

          Daily subcutaneous injections of parathyroid hormone (PTH), and its synthetic peptide fragment, teriparatide (PTH 1-34, TPTD), have a net anabolic effect on bone and prevent osteoporotic fractures. TPTD is currently approved for this indication worldwide. Because of the anabolic effect, there is an interest in a role for TPTD (and, where available, human PTH 1-84) in improving bone healing after a fracture. PTH has been studied in animal fracture healing models and in a limited number of human trials. We have reviewed current literature regarding possible mechanisms and efficacy for PTH and TPTD to improve the healing process in the setting of various types of fractures.

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          Author and article information

          Journal
          Expert Opin Biol Ther
          Expert opinion on biological therapy
          1744-7682
          1471-2598
          Jan 2015
          : 15
          : 1
          Affiliations
          [1 ] University of Calgary, Cumming School of Medicine , 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 , Canada.
          Article
          10.1517/14712598.2015.977249
          25363308
          0a40f4af-6087-43d1-b9fe-568bc91c6845
          History

          fracture healing,nonunion,parathyroid hormone,teriparatide

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