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      Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

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          Abstract

          We previously established long-term culture conditions under which single crypts or stem cells derived from mouse small intestine expand over long periods. The expanding crypts undergo multiple crypt fission events, simultaneously generating villus-like epithelial domains that contain all differentiated types of cells. We have adapted the culture conditions to grow similar epithelial organoids from mouse colon and human small intestine and colon.

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          Author and article information

          Journal
          Gastroenterology
          Gastroenterology
          Elsevier BV
          1528-0012
          0016-5085
          Nov 2011
          : 141
          : 5
          Affiliations
          [1 ] Hubrecht Institute, KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands. t.sato@a7.keio.jp
          Article
          S0016-5085(11)01108-5
          10.1053/j.gastro.2011.07.050
          21889923
          0a46df13-5f5a-4beb-b35b-6bd0be37ace5
          Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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