An exploratory analysis of alkaline phosphatase, lactate dehydrogenase, and prostate-specific antigen dynamics in the phase 3 ALSYMPCA trial with radium-223.

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Abstract

Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, such as radium-223, is not established.

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Journal

Journal ID (iso-abbrev): Ann. Oncol.

Title: Annals of oncology : official journal of the European Society for Medical Oncology

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1569-8041

ISSN (Print): 0923-7534

Publication date (Electronic): May 01 2017

Volume: 28

Issue: 5

Affiliations

[1 ] Departments of Medicine and Urology, Tulane Cancer Center, New Orleans, USA.

[2 ] Academic Unit of Clinical Oncology, University of Sheffield, Weston Park Hospital, Sheffield, UK.

[3 ] Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.

[4 ] Department of Oncology, Akershus University Hospital, Lørenskog.

[5 ] Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway.

[6 ] Department of Clinical Oncology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland.

[7 ] Department of Medical Oncology, Comprehensive Cancer Centers of Nevada, Las Vegas, USA.

[8 ] Department of Medical Oncology and Radiotherapy, University of Oslo, Norwegian Radium Hospital, Oslo, Norway.

[9 ] Oncology Global Medical Affairs, Bayer HealthCare Pharmaceuticals, Whippany.

[10 ] Infinity Analytics Group Inc, Madison.

[11 ] Department of Statistics, Oncology, Bayer HealthCare Pharmaceuticals, Whippany.

[12 ] Quantitative Health Sciences, Cleveland Clinic, Cleveland, USA.

[13 ] Academic Urology Unit, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, UK.

Article

Publisher Item ID: 3001411

DOI: 10.1093/annonc/mdx044

PMC ID: 5406754

PubMed ID: 28453701

SO-VID: 0a475f20-79c9-444f-bd29-cc7340e3e20b

History

Keywords: ALSYMPCA,CRPC,alkaline phosphatase,lactate dehydrogenase,prostate-specific antigen,radium-223

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Keywords: ALSYMPCA, CRPC, alkaline phosphatase, lactate dehydrogenase, prostate-specific antigen, radium-223

An exploratory analysis of alkaline phosphatase, lactate dehydrogenase, and prostate-specific antigen dynamics in the phase 3 ALSYMPCA trial with radium-223.

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