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      Human brain mechanisms of pain perception and regulation in health and disease.

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          Abstract

          The perception of pain due to an acute injury or in clinical pain states undergoes substantial processing at supraspinal levels. Supraspinal, brain mechanisms are increasingly recognized as playing a major role in the representation and modulation of pain experience. These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic pain conditions.

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          Author and article information

          Journal
          Eur J Pain
          European journal of pain (London, England)
          Elsevier BV
          1090-3801
          1090-3801
          Aug 2005
          : 9
          : 4
          Affiliations
          [1 ] Department of Physiology, Northwestern University Medical School, 303 E. Chicago Avenue, Ward 5-003, Chicago, IL 60611, USA. a-apkarian@northwestern.edu
          Article
          S1090-3801(04)00148-X
          10.1016/j.ejpain.2004.11.001
          15979027
          0a594f12-714b-4144-8251-8f92e07d855d

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